The VBP101 clinical trial is actively enrolling patients. This trial will provide important validating evidence of the potential of trem-cel and our broader shielded transplant approach.
Study goals
The key goals of the VBP101 trial are to evaluate tolerability and feasibility of allogeneic HCT with trem-cel, with a focus on timely neutrophil engraftment after trem-cel infusion. Once successfully engrafted with trem-cel, patients are eligible for subsequent treatment with Mylotarg as maintenance therapy or as treatment for relapse post-HCT. In patients receiving Mylotarg, we are examining the incidence of hematologic toxicities and determining the appropriate maintenance dose. Any observed protection from such on-target toxicity in this Phase 1/2a trial serves as an important proof of principle for our research and development platform. While this trial is not powered to confirm significance of efficacy, relapse-free survival and overall survival is being assessed.
Enrollment & follow-up
The VBP101 trial (NCT04849910) is open to AML and MDS patients who are at high risk of relapse and undergoing myeloablative hematopoietic stem cell transplant (HCT). Participants (18-70 years old) must have a diagnosis of CD33+ AML or MDS, an HLA-matched related or unrelated (8/8) donor and be a candidate for myeloablative HCT. Additional key inclusion criteria include morphologic remission with adverse risk factors for relapse. Patients with 5-10% bone marrow-only blasts with any cytogenetic risk are also eligible. Key exclusion criteria include prior auto/allo-HCT or treatment with Mylotarg.
To administer trem-cel, HSCs from matched healthy donors are mobilized and isolated from peripheral blood, engineered into trem-cel and then introduced into patients following myeloablative conditioning. As a safety measure, a portion of the original unmanipulated donor cells are frozen and stored as a backup graft.
At day 60, patients are re-evaluated for disease status and are examined for CD33-negative peripheral blood counts. Those patients remaining in remission and meeting dosing criteria are treated with maintenance doses (escalated in separate dosing cohorts) of Mylotarg once a month for four months to potentially reduce the risk of relapse by killing any residual AML cells. Patients who become measurable residual disease (MRD) positive or relapse also have the option to receive induction-course Mylotarg or VCAR33ALLO, Vor Bio’s donor-derived CD33-directed CAR-T drug candidate. Patients are followed for two years after HCT and for up to 15 years post-HCT in a separate long-term follow-up study.