VADC45

VADC45 is a novel antibody drug conjugate (ADC) with pan-isoform anti-CD45 selectivity.

We are developing VADC45 as an ADC that targets the CD45 protein.

VADC45 is composed of a human IgG1 antibody attached to the DGN549-C linker-payload, which has been used in two clinical-stage ADCs. VADC45 has been engineered to have a short half-life but highly specific to bind human CD45, which is expressed on normal hematopoietic stem and progenitor cells (HSPCs) and immune cells, including mature myeloid and lymphoid cells.

CD45 is an attractive target for conditioning of HSPCs and immune cells prior to hematopoietic cell transplant (HCT), with the potential to prevent allograft rejection and to improve outcomes with an improved safety and tolerability profile.

VADC45 Development

VADC has the potential to treat a number of diseases, including treatment of hematologic malignancies, as a targeted conditioning agent for gene therapies such as for sickle cell disease, holistic immune reset for autoimmune disorders, and for Vor Bio’s approach of combining this asset with epitope modification of CD45 to shield healthy stem cells.

We are progressing IND enabling studies to enable future Phase 1 studies.

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Next In Our Pipeline

CD33-CLL1 Multiplex Treatment System